Topical Anesthetics & Analgesics

Pain management often involves oral pain medications, but this can come with many side effects.  The use of topical agents can help avoid systemic side effects while still being successful in managing pain. Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats.
https://www.ncbi.nlm.nih.gov/pubmed?term=12761001

Topical amitriptyline in healthy volunteers.
https://www.ncbi.nlm.nih.gov/pubmed?term=12945021

Topical analgesics.
https://www.ncbi.nlm.nih.gov/pubmed?term=22440379

Local application of strong opioids and wound-related pain.
https://www.ncbi.nlm.nih.gov/pubmed?term=22216634 

Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist–loperamide.
https://www.ncbi.nlm.nih.gov/pubmed?term=9915332