Topical Anesthetics & Analgesics

Pain management often involves oral pain medications, but this can come with many side effects.  The use of topical agents can help avoid systemic side effects while still being successful in managing pain. Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats.

Topical amitriptyline in healthy volunteers.

Topical analgesics.

Local application of strong opioids and wound-related pain. 

Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist–loperamide.


This condition that causes excessive can be harmful psychologically and social for the person it affects. This could be an especially harmful problem with athletes. Topical treatments are the most common treatment and compounded possibilities include aluminum chloride solutions or topical methenamine.

Comparison of topical methenamine, glutaraldehyde and tap water Iontophoresis for palmoplantar hyperhidrosis.

Treatment options for hyperhidrosis

NSAID Therapy

NSAIDs are some of the most commonly prescribed pain and anti-inflammatory drugs, but they can have serious side effects especially for the gastro-intestinal system.  Compounded topical application of these same drugs can prove to be as beneficial as when taken orally without the complications of systemic side effects.Topical Nonsteroidal Anti-Inflammatory Drugs: The Importance of Drug, Delivery, and Therapeutic Outcome.

Coming to terms with nonsteroidal anti-inflammatory drug gastropathy.

Evolution of Topical NSAIDs in the Guidelines for Treatment of Osteoarthritis in Elderly Patients.

Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs.

Plantar Fasciitis

Plantar fasciitis can be very painful and sometimes debilitating.  Treatments often take several weeks if not longer to see results and usually require a reduction in activity.  Athletes especially often want faster results for this condition and new opportunities with iontophoresis and compounded topical medications may achieve that. Treatment of plantar fasciitis by iontophoresis of 0.4% dexamethasone. A randomized, double-blind, placebo-controlled study.