Acne

Acne, a very common problem especially in teenagers, has many possible treatments available, but for multiple reasons an alternative may be needed. Many treatments for acne involve the use of antibiotics, which may have additional side effects and the use of which may contribute the emergence of resistant microbes. A compounded, non-antibiotic topical treatment could be a useful alternative. In some cases common treatments simply do not work well enough. Combinations of creams may prove to be more successful than current therapy. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris.
https://www.ncbi.nlm.nih.gov/pubmed?term=7657446

A 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm) in acne vulgaris: a randomized, double-blind comparative study.
https://www.ncbi.nlm.nih.gov/pubmed?term=2533878

Pulmonary Arterial Hypertension

Most medications on the market for pulmonary hypertension are not made in appropriate strengths or forms for use in children. Medications can be compounded to make them child appropriate including new therapies emerging like sildenafil. The use of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of the Newborn: A Review of the Literature.
https://www.ncbi.nlm.nih.gov/pubmed?term=22564297 

Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: twelve-month clinical trial of a single-drug, open-label, pilot study.
https://www.ncbi.nlm.nih.gov/pubmed?term=15956137

Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension.
https://www.ncbi.nlm.nih.gov/pubmed?term=19768639

Molluscum Contagiosum

This skin condition is currently rarely treated as it is usually a self-limiting infection. Sometimes an infection can cause secondary skin infections, or the infection may not go away on its own if the patient’s immune system is weak. In these cases treatment may be necessary. Treatment of molluscum contagiosum with silver nitrate paste.
https://www.ncbi.nlm.nih.gov/pubmed?term=10571843

Head Lice

Common treatments of head lice use a pediculicide that works as a neurotoxic agent against the lice to kill them.  This treatment can both raise concerns for the patient being treated and can be ineffective against resistant populations. Compounded products that work in a different way can offer new alternatives. Pediculosis capitis: new insights into epidemiology, diagnosis and treatment.

https://www.ncbi.nlm.nih.gov/pubmed?term=22382818

Effectiveness of lotions based on essential oils from aromatic plants against permethrin resistant Pediculus humanus capitis.
https://www.ncbi.nlm.nih.gov/pubmed?term=17647002

Fungal Skin Infections

Fungus can cause many infections like athlete’s foot, ringworm, jock itch, and others. Many over the counter and prescription treatments are available, but as resistant strains are found a new treatment may need to be used. The combination of the usual antifungal and ibuprofen has been shown to be a successful alternative. Antifungal activity of ibuprofen alone and in combination with fluconazole against Candida species.
https://www.ncbi.nlm.nih.gov/pubmed?term=10966233

Diaper Rash

Diaper rash is a very common but often troublesome problem for infants.  Compounded cholestyramine products have been shown to be a successful alternative to current market products. Cholestyramine ointment to treat buttocks rash and anal excoriation in an infant.
https://www.ncbi.nlm.nih.gov/pubmed?term=8876854

Autism

Dietary supplements of vitamins and amino acids can be used to help reduce symptoms in autistic patients. Through compounding we can create strengths and routes of administration to specifically meet patients’ needs.  Alternative therapies could also be made.

Proposed remedies for some developmental disorders.
https://www.ncbi.nlm.nih.gov/pubmed?term=22301819 

Transdermal secretin for autism – a case report.
https://www.ncbi.nlm.nih.gov/pubmed?term=11410075

Anti-emetics

Treatments for nausea and vomiting can include some oral medications, rectal suppositories, and IV combinations.  Through compounding new routes of administration or combinations can be made, including transdermal and intranasal routes. Oral combination antiemetics in patients with small cell lung cancer receiving cisplatin or cyclophosphamide plus doxorubicin.
https://www.ncbi.nlm.nih.gov/pubmed?term=8625179

Intranasal metoclopramide.
https://www.ncbi.nlm.nih.gov/pubmed?term=10473023

Nasal absorption of ondansetron in rats: an alternative route of drug delivery.
https://www.ncbi.nlm.nih.gov/pubmed?term=10803929

Bioavailability of Promethazine in a Topical Pluronic Lecithin Organogel: A Pilot Study
https://www.ijpc.com/abstracts/abstract.cfm?ABS=2203

ADHD & ADD

With a growing number of children being diagnosed and treated for ADHD and ADD a need for new therapies may be needed. Most often children are treated with psychostimulants which could be compounded into route or specific dosing for a child if their needs are not met through marketed products. For children who can not tolerate, or wish to avoid, psychostimulants alternatives like zinc can be made.Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder.
https://www.ncbi.nlm.nih.gov/pubmed?term=14687872

Topical Anesthetics & Analgesics

Pain management often involves oral pain medications, but this can come with many side effects. The use of topical agents can help avoid systemic side effects while still being successful in managing pain. Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats.
https://www.ncbi.nlm.nih.gov/pubmed?term=12761001 

Topical amitriptyline in healthy volunteers.
https://www.ncbi.nlm.nih.gov/pubmed?term=12945021 

Topical analgesics.
https://www.ncbi.nlm.nih.gov/pubmed?term=22440379

Local application of strong opioids and wound-related pain.
https://www.ncbi.nlm.nih.gov/pubmed?term=22216634 

Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist–loperamide.
https://www.ncbi.nlm.nih.gov/pubmed?term=9915332