For patients with migraines finding a successful treatment without side effects can be difficult. Combination drugs may be helpful, but a commonly used one, Midrin, is not currently available. Another common treatment includes triptans, like sumatriptan, which may cause serious cardiovascular side effects. Compounding can offer other treatment options or replace ones not on the current market. Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine versus sumatriptan in acute treatment of multiple migraine attacks: a multicenter, randomized, crossover trial.
https://www.ncbi.nlm.nih.gov/pubmed?term=12940804
