Hormone replacement therapy in women to help with menopause symptoms has become very common, but concerns about health risks of these supplements currently on the market have created a need for alternatives. An example of these risks is the elevated incidence of venous thrombosis with the use of conjugated equine estrogen (found in Premarin). The use of bioidentical hormones is a safer alternative to products like this and has shown better results than marketed estrogen supplements.
Bioidentical hormone therapy.
https://www.ncbi.nlm.nih.gov/pubmed?term=21531972
Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis.
https://www.ncbi.nlm.nih.gov/pubmed?term=15467060
Effectiveness of compounded bioidentical hormone replacement therapy: an observational cohort study.
https://www.ncbi.nlm.nih.gov/pubmed?term=21651797