As men age their natural production of testosterone can decrease resulting in symptomatic andropause. This is usually treated with testosterone replacement therapy. This therapy can give good effects, but also can produce adverse effects, partially from testosterone converting to estrogen thereby increases the man’s estrogen levels. By combining the usual testosterone with an aromatase inhibitor, like chrysin, this conversion can be stopped or reduced so the risks of prostate cancer and blood clots that usually accompany testosterone therapy can be reduced.

Treatment of patients with andropause

Male hormone replacement therapy including “andropause”.

Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells

Facile synthesis of chrysin-derivatives with promising activities as aromatase inhibitors.