While topical treatments are often preferred for skin conditions like psoriasis, current treatments of moisturizing and scale removal may not be enough. Compounded topical prescriptions like sirolimus may offer a more effective treatment without systemic side effects. Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial.
https://www.ncbi.nlm.nih.gov/pubmed?term=15840110
