The treatment of nail fungal infection usually has very low success rates, has high relapse rates, and often has many side effects since usually it is treated with an oral antifungal.  Newer methods that can be made with compounding can decrease or eliminate the side effects of traditional oral therapy while also achieving good results. New therapeutic options for onychomycosis.

Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream.

A comparative evaluation of combination therapy of fluconazole 1% and urea 40% compared with fluconazole 1% alone in a nail lacquer for treatment of onychomycosis: therapeutic trial.