Acne, a very common problem especially in teenagers, has many possible treatments available, but for multiple reasons an alternative may be needed. Many treatments for acne involve the use of antibiotics, which may have additional side effects and the use of which may contribute to the emergence of resistant microbes. A compounded, non-antibiotic topical treatment could be a useful alternative.  In some cases common treatments simply do not work well enough.  Combinations of creams may prove to be more successful than current therapy.Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. 

A 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm) in acne vulgaris: a randomized, double-blind comparative study.