While topical treatments are often preferred for skin conditions like psoriasis, current treatments of moisturizing and scale removal may not be enough.  Compounded topical prescriptions like sirolimus may offer a more effective treatment without systemic side effects. Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial.


Rosacea treatment can include trigger avoidance, oral antibiotics, and surgery if severe.  Each of these treatments can be ineffective or undesirable due to side effects.  A topical treatment may be a better method of treatment for some patients. A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks.

Scarring and Keloids

Current treatments to remove scars and keloids are often ineffective and can leave behind damage or discoloration of their own.  The use of chemotherapy agents like tamoxifen has shown successful results in decreasing the growth of keloids without the side effects of other treatments. Tamoxifen downregulates TGF-beta production in keloid fibroblasts.

Skin Aging

Reversing and preventing the visible aging of skin is a major concern for many adults.  These signs can be from normal aging or excessive sun exposure.  Regardless of the cause compounded treatments can offer treatments not found elsewhere. Treatment of skin aging with topical estrogens.

Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin.


Vitiligo is currently very difficult to treat with current treatment methods often being ineffective.  Treatment with pseudocatalase and UVB exposure has shown to both repigment skin that has been affected and new areas from being effected. Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients.


This very common viral infection can sometimes be difficult to treat due to resistant warts or if a patient has multiple warts.  Often surgical options are used in these cases, but this may be undesirable to the patient.  In these cases squaric acid used topically is showing to be a good alternative. Squaric acid immunotherapy for warts in children. 

Use of squaric acid dibutylester (SADBE) for cutaneous warts in children.


Acne, a very common problem especially in teenagers, has many possible treatments available, but for multiple reasons an alternative may be needed. Many treatments for acne involve the use of antibiotics, which may have additional side effects and the use of which may contribute to the emergence of resistant microbes. A compounded, non-antibiotic topical treatment could be a useful alternative.  In some cases common treatments simply do not work well enough.  Combinations of creams may prove to be more successful than current therapy.Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. 

A 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm) in acne vulgaris: a randomized, double-blind comparative study.

Chemical Peels

Chemical peels have become a more popular way to treat many skin conditions.  While usually performed in a doctor’s office the preparation of the chemicals can be done at a compounding pharmacy. The use of chemical peelings in the treatment of different cutaneous hyperpigmentations.

Chronic Pruritus

Chronic itching is a common problem that can come from many different sources like dermatitis, psoriasis, or as a side effect of chronic opioid use. Treatment often includes corticosteroids or antihistamines, but these can be unsatisfactory in some patients who will then need a more individualized treatment. Options that can be compounded would include a topical naltrexone cream, topical immunomodulators, urea creams, topical anesthetics, and many more.

Treatment of pruritus with topically applied opiate receptor antagonist.

Diaper Rash and Incontinence

Rashes can commonly be found in both infants and adults with incontinence.  Compounded cholestyramine products have been shown to be a successful alternative to current market products. Cholestyramine ointment to treat buttocks rash and anal excoriation in an infant.

Cholestyramine ointment in the treatment of perianal skin irritation following ileoanal anastomosis.