These mouth diseases can be both painful and cause serious side effects of not treated. Hygiene and dentist treatments are currently the main treatments, but research is showing adjunct pharmacological therapy along with the current regimens will increase patient response. A comparative evaluation of atrigel delivery system (10% doxycycline hyclate) Atridox with scaling and root planing and combination therapy in treatment of periodontitis: A clinical study.
https://www.ncbi.nlm.nih.gov/pubmed?term=22628962
Folate mouthwash: effects on established gingivitis in periodontal patients.
https://www.ncbi.nlm.nih.gov/pubmed?term=6386897